Reviews Antihemophilic Factor


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Alphanate Drug Description
ALPHANATE©
(antihemophilic factor) (HUMAN)
Solvent Detergent / Heat Treated
DRUG DESCRIPTION



What are the possible side effects of antihemophilic factor (factor VIII)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever, chills, runny nose, and drowsiness followed about 2 weeks later by a rash and joint pain;
fast...
Read All Potential Side Effects for Alphanate »




Antihemophilic Factor (Human), Alphanate®, Solvent Detergent / Heat Treated, is a single dose, sterile, lyophilized concentrate of Factor VIII (AHF) intended for intravenous administration in the treatment of hemophilia A, or acquired Factor VIII deficiency.
Alphanate® is prepared from pooled human plasma by cryoprecipitation of
the Factor VIII, fractional solubilization, and further purification employing
heparin-coupled, cross-linked agarose which has an affinity to the heparin binding
domain of vWf/FVIII:C complex.1 The product is treated with a mixture
of tri(n-butyl) phosphate (TNBP) and polysorbate 80 to reduce the risks of transmission
of viral infection. In order to provide an additional safeguard against potential
non-lipid enveloped viral contaminants, the product is also subjected to a 80
°C heat treatment step for 72 hours. However, no procedure has been shown
to be totally effective in removing viral infectivity from coagulation factor
products.
Alphanate® is labeled with the antihemophilic factor potency (Factor VIIIC
activity) expressed in International Units (I U) per vial, which is referenced
to the WHO International Standard.
Alphanate® contains Albumin (Human) as a stabilizer, resulting in a final container concentrate with a specific activity of at least 5 IU FVIII:C/mg total protein. Prior to the addition of the Albumin (Human) stabilizer, the specific activity is significantly higher.
When reconstituted with the appropriate volume of Sterile Water for Injection,
USP, Alphanate® contains 0.3 - 0.9 g Albumin (Human)/100 mL; NMT 5 mmol
calcium/L; NMT 750 µg glycine/IU FVIIIC; NMT 1.0 U heparin/mL; 10 - 40
mmol histidine/L; NMT 0.1 mg imidazole/mL; 50 - 200 mmol arginine/L; NMT 1.0
µg polyethylene glycol and polysorbate 80/IU FVIII:C; NMT 10 mEq sodium/vial;
and NMT 0.1 µg TNBP/IU FVIIIC.
REFERENCES
1. Fujimura, Y., Titani, K., Holland, L.Z., Roberts, J.R.,
Kostel, P., Ruggeri, Z.M., Zimmerman, T.S. A Heparin-Binding Domain of Human
Von Willebrand Factor: Characterization and Localization to a Tryptic Fragment
Extending from Amino Acid Residue Val-449 to Lys-728. I Biol Chem 1987, 262(4):
1 734-1 739.Last reviewed on RxList: 11/14/2008




Alphanate Drug Description
ALPHANATE©
(antihemophilic factor) (HUMAN)
Solvent Detergent / Heat Treated
DRUG DESCRIPTION



What are the possible side effects of antihemophilic factor (factor VIII)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever, chills, runny nose, and drowsiness followed about 2 weeks later by a rash and joint pain;
fast...
Read All Potential Side Effects for Alphanate »




Antihemophilic Factor (Human), Alphanate®, Solvent Detergent / Heat Treated, is a single dose, sterile, lyophilized concentrate of Factor VIII (AHF) intended for intravenous administration in the treatment of hemophilia A, or acquired Factor VIII deficiency.
Alphanate® is prepared from pooled human plasma by cryoprecipitation of
the Factor VIII, fractional solubilization, and further purification employing
heparin-coupled, cross-linked agarose which has an affinity to the heparin binding
domain of vWf/FVIII:C complex.1 The product is treated with a mixture
of tri(n-butyl) phosphate (TNBP) and polysorbate 80 to reduce the risks of transmission
of viral infection. In order to provide an additional safeguard against potential
non-lipid enveloped viral contaminants, the product is also subjected to a 80
°C heat treatment step for 72 hours. However, no procedure has been shown
to be totally effective in removing viral infectivity from coagulation factor
products.
Alphanate® is labeled with the antihemophilic factor potency (Factor VIIIC
activity) expressed in International Units (I U) per vial, which is referenced
to the WHO International Standard.
Alphanate® contains Albumin (Human) as a stabilizer, resulting in a final container concentrate with a specific activity of at least 5 IU FVIII:C/mg total protein. Prior to the addition of the Albumin (Human) stabilizer, the specific activity is significantly higher.
When reconstituted with the appropriate volume of Sterile Water for Injection,
USP, Alphanate® contains 0.3 - 0.9 g Albumin (Human)/100 mL; NMT 5 mmol
calcium/L; NMT 750 µg glycine/IU FVIIIC; NMT 1.0 U heparin/mL; 10 - 40
mmol histidine/L; NMT 0.1 mg imidazole/mL; 50 - 200 mmol arginine/L; NMT 1.0
µg polyethylene glycol and polysorbate 80/IU FVIII:C; NMT 10 mEq sodium/vial;
and NMT 0.1 µg TNBP/IU FVIIIC.
REFERENCES
1. Fujimura, Y., Titani, K., Holland, L.Z., Roberts, J.R.,
Kostel, P., Ruggeri, Z.M., Zimmerman, T.S. A Heparin-Binding Domain of Human
Von Willebrand Factor: Characterization and Localization to a Tryptic Fragment
Extending from Amino Acid Residue Val-449 to Lys-728. I Biol Chem 1987, 262(4):
1 734-1 739.Last reviewed on RxList: 11/14/2008




Alphanate Drug Description
ALPHANATE©
(antihemophilic factor) (HUMAN)
Solvent Detergent / Heat Treated
DRUG DESCRIPTION



What are the possible side effects of antihemophilic factor (factor VIII)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever, chills, runny nose, and drowsiness followed about 2 weeks later by a rash and joint pain;
fast...
Read All Potential Side Effects for Alphanate »




Antihemophilic Factor (Human), Alphanate®, Solvent Detergent / Heat Treated, is a single dose, sterile, lyophilized concentrate of Factor VIII (AHF) intended for intravenous administration in the treatment of hemophilia A, or acquired Factor VIII deficiency.
Alphanate® is prepared from pooled human plasma by cryoprecipitation of
the Factor VIII, fractional solubilization, and further purification employing
heparin-coupled, cross-linked agarose which has an affinity to the heparin binding
domain of vWf/FVIII:C complex.1 The product is treated with a mixture
of tri(n-butyl) phosphate (TNBP) and polysorbate 80 to reduce the risks of transmission
of viral infection. In order to provide an additional safeguard against potential
non-lipid enveloped viral contaminants, the product is also subjected to a 80
°C heat treatment step for 72 hours. However, no procedure has been shown
to be totally effective in removing viral infectivity from coagulation factor
products.
Alphanate® is labeled with the antihemophilic factor potency (Factor VIIIC
activity) expressed in International Units (I U) per vial, which is referenced
to the WHO International Standard.
Alphanate® contains Albumin (Human) as a stabilizer, resulting in a final container concentrate with a specific activity of at least 5 IU FVIII:C/mg total protein. Prior to the addition of the Albumin (Human) stabilizer, the specific activity is significantly higher.
When reconstituted with the appropriate volume of Sterile Water for Injection,
USP, Alphanate® contains 0.3 - 0.9 g Albumin (Human)/100 mL; NMT 5 mmol
calcium/L; NMT 750 µg glycine/IU FVIIIC; NMT 1.0 U heparin/mL; 10 - 40
mmol histidine/L; NMT 0.1 mg imidazole/mL; 50 - 200 mmol arginine/L; NMT 1.0
µg polyethylene glycol and polysorbate 80/IU FVIII:C; NMT 10 mEq sodium/vial;
and NMT 0.1 µg TNBP/IU FVIIIC.
REFERENCES
1. Fujimura, Y., Titani, K., Holland, L.Z., Roberts, J.R.,
Kostel, P., Ruggeri, Z.M., Zimmerman, T.S. A Heparin-Binding Domain of Human
Von Willebrand Factor: Characterization and Localization to a Tryptic Fragment
Extending from Amino Acid Residue Val-449 to Lys-728. I Biol Chem 1987, 262(4):
1 734-1 739.Last reviewed on RxList: 11/14/2008




Alphanate Drug Description
ALPHANATE©
(antihemophilic factor) (HUMAN)
Solvent Detergent / Heat Treated
DRUG DESCRIPTION



What are the possible side effects of antihemophilic factor (factor VIII)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever, chills, runny nose, and drowsiness followed about 2 weeks later by a rash and joint pain;
fast...
Read All Potential Side Effects for Alphanate »




Antihemophilic Factor (Human), Alphanate®, Solvent Detergent / Heat Treated, is a single dose, sterile, lyophilized concentrate of Factor VIII (AHF) intended for intravenous administration in the treatment of hemophilia A, or acquired Factor VIII deficiency.
Alphanate® is prepared from pooled human plasma by cryoprecipitation of
the Factor VIII, fractional solubilization, and further purification employing
heparin-coupled, cross-linked agarose which has an affinity to the heparin binding
domain of vWf/FVIII:C complex.1 The product is treated with a mixture
of tri(n-butyl) phosphate (TNBP) and polysorbate 80 to reduce the risks of transmission
of viral infection. In order to provide an additional safeguard against potential
non-lipid enveloped viral contaminants, the product is also subjected to a 80
°C heat treatment step for 72 hours. However, no procedure has been shown
to be totally effective in removing viral infectivity from coagulation factor
products.
Alphanate® is labeled with the antihemophilic factor potency (Factor VIIIC
activity) expressed in International Units (I U) per vial, which is referenced
to the WHO International Standard.
Alphanate® contains Albumin (Human) as a stabilizer, resulting in a final container concentrate with a specific activity of at least 5 IU FVIII:C/mg total protein. Prior to the addition of the Albumin (Human) stabilizer, the specific activity is significantly higher.
When reconstituted with the appropriate volume of Sterile Water for Injection,
USP, Alphanate® contains 0.3 - 0.9 g Albumin (Human)/100 mL; NMT 5 mmol
calcium/L; NMT 750 µg glycine/IU FVIIIC; NMT 1.0 U heparin/mL; 10 - 40
mmol histidine/L; NMT 0.1 mg imidazole/mL; 50 - 200 mmol arginine/L; NMT 1.0
µg polyethylene glycol and polysorbate 80/IU FVIII:C; NMT 10 mEq sodium/vial;
and NMT 0.1 µg TNBP/IU FVIIIC.
REFERENCES
1. Fujimura, Y., Titani, K., Holland, L.Z., Roberts, J.R.,
Kostel, P., Ruggeri, Z.M., Zimmerman, T.S. A Heparin-Binding Domain of Human
Von Willebrand Factor: Characterization and Localization to a Tryptic Fragment
Extending from Amino Acid Residue Val-449 to Lys-728. I Biol Chem 1987, 262(4):
1 734-1 739.Last reviewed on RxList: 11/14/2008




Alphanate Drug Description
ALPHANATE©
(antihemophilic factor) (HUMAN)
Solvent Detergent / Heat Treated
DRUG DESCRIPTION



What are the possible side effects of antihemophilic factor (factor VIII)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever, chills, runny nose, and drowsiness followed about 2 weeks later by a rash and joint pain;
fast...
Read All Potential Side Effects for Alphanate »




Antihemophilic Factor (Human), Alphanate®, Solvent Detergent / Heat Treated, is a single dose, sterile, lyophilized concentrate of Factor VIII (AHF) intended for intravenous administration in the treatment of hemophilia A, or acquired Factor VIII deficiency.
Alphanate® is prepared from pooled human plasma by cryoprecipitation of
the Factor VIII, fractional solubilization, and further purification employing
heparin-coupled, cross-linked agarose which has an affinity to the heparin binding
domain of vWf/FVIII:C complex.1 The product is treated with a mixture
of tri(n-butyl) phosphate (TNBP) and polysorbate 80 to reduce the risks of transmission
of viral infection. In order to provide an additional safeguard against potential
non-lipid enveloped viral contaminants, the product is also subjected to a 80
°C heat treatment step for 72 hours. However, no procedure has been shown
to be totally effective in removing viral infectivity from coagulation factor
products.
Alphanate® is labeled with the antihemophilic factor potency (Factor VIIIC
activity) expressed in International Units (I U) per vial, which is referenced
to the WHO International Standard.
Alphanate® contains Albumin (Human) as a stabilizer, resulting in a final container concentrate with a specific activity of at least 5 IU FVIII:C/mg total protein. Prior to the addition of the Albumin (Human) stabilizer, the specific activity is significantly higher.
When reconstituted with the appropriate volume of Sterile Water for Injection,
USP, Alphanate® contains 0.3 - 0.9 g Albumin (Human)/100 mL; NMT 5 mmol
calcium/L; NMT 750 µg glycine/IU FVIIIC; NMT 1.0 U heparin/mL; 10 - 40
mmol histidine/L; NMT 0.1 mg imidazole/mL; 50 - 200 mmol arginine/L; NMT 1.0
µg polyethylene glycol and polysorbate 80/IU FVIII:C; NMT 10 mEq sodium/vial;
and NMT 0.1 µg TNBP/IU FVIIIC.
REFERENCES
1. Fujimura, Y., Titani, K., Holland, L.Z., Roberts, J.R.,
Kostel, P., Ruggeri, Z.M., Zimmerman, T.S. A Heparin-Binding Domain of Human
Von Willebrand Factor: Characterization and Localization to a Tryptic Fragment
Extending from Amino Acid Residue Val-449 to Lys-728. I Biol Chem 1987, 262(4):
1 734-1 739.Last reviewed on RxList: 11/14/2008





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Other reviews about Antihemophilic Factor on web:

Factor VIII (FVIII) is an essential blood clotting factor also known as anti-hemophilic factor (AHF). In humans, Factor VIII is encoded by the F8 gene. Factor VIII - Wikipedia, the free encyclopedia


an脗路ti脗路he脗路mo脗路phil脗路ic factor (n t-h m-f l k, n t-) n. Abbr. AHF. A protein substance in blood plasma that participates in and is essential for the blood-clotting process. antihemophilic factor - definition of antihemophilic factor by the ...


Physician reviewed antihemophilic factor (human) patient information - includes antihemophilic factor description, dosage and directions. antihemophilic factor (human) medical facts from Drugs.com


Antihemophilic factor is a naturally occurring protein in the blood that helps blood to clot. A lack of antihemophilic factor VIII is the cause of hemophilia A. antihemophilic factor Information - Drugs and Treatments - MedHelp


Information for patients from the National Library of Medicine. Antihemophilic Factor (Human): MedlinePlus Drug Information


Antihemophilic Factor, AHF, Factor VIII injection To return to the main entry click here . What is antihemophilic factor injection? Antihemophilic Antihemophilic Factor, AHF, Factor VIII injection: Information ...


factor /fac脗路tor/ (fak脗麓ter) an agent or element that contributes to the production of a result. accelerator factor coagulation f. V. angiogenesis factor a substance that causes ... antihemophilic factor - definition of antihemophilic factor in the ...


Consumer information about the medication ANTIHEMOPHILIC FACTOR, RECOMBINANT - INJECTION (Bioclate, Helixate, Kogenate, Recombinate), includes side effects, drug interactions ... ANTIHEMOPHILIC FACTOR, RECOMBINANT - INJECTION (Bioclate, Helixate ...


factor VIII n antihemophilic factor [AHF], antihemophilic globulin, antihemophilic globulin A, antihemophilic factor A, plasma thromboplastin factor Factor VIII: Definition from Answers.com


Your doctor has ordered antihemophilic factor (recombinant) to help your blood to clot. The drug will be either injected directly into your vein or added to an intravenous fluid ... Antihemophilic Factor (Recombinant): MedlinePlus Drug Information





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