Reviews Amprenavir Oral Solution


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Agenerase Oral Solution Drug Description
AGENERASE®
(amprenavir) Oral Solution

Because of the potential risk of toxicity from the large amount of the excipient,
propylene glycol, AGENERASE Oral Solution is contraindicated in infants and
children below the age of 4 years, pregnant women, patients with hepatic or
renal failure, and patients treated with disulfiram or metronidazole (see CONTRAINDICATIONS
AND WARNINGS). AGENERASE Oral Solution should be used only when AGENERASE
Capsules or other protease inhibitor formulations are not therapeutic options.


DRUG DESCRIPTION



What are the possible side effects of amprenavir (Agenerase)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking amprenavir and call your doctor at once if you have any of these serious side effects:

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
pale or yellowed skin, dark colored urine, fever, confusion or weakness;
increased urination or extreme thirst;
...
Read All Potential Side Effects for Agenerase Oral Solution »




AGENERASE (amprenavir) is an inhibitor of the human immunodeficiency virus
(HIV) protease. The chemical name of amprenavir is (3S)-tetrahydro-3-furyl
N-[(1S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl]carbamate.
Amprenavir is a single stereoisomer with the (3S)(1S,2R)
configuration. It has a molecular formula of C25H35N3O6S
and a molecular weight of 505.64. It has the following structural formula:








Amprenavir is a white to cream-colored solid with a solubility of approximately
0.04 mg/mL in water at 25°C.
AGENERASE Oral Solution is for oral administration. One milliliter (1
mL) of AGENERASE Oral Solution contains 15 mg of amprenavir in solution and
the inactive ingredients acesulfame potassium, artificial grape bubblegum flavor,
citric acid (anhydrous), d-alpha tocopheryl polyethylene glycol 1000 succinate
(TPGS), menthol, natural peppermint flavor, polyethylene glycol 400 (PEG 400)
(170 mg), propylene glycol (550 mg), saccharin sodium, sodium chloride, and
sodium citrate (dihydrate). Solutions of sodium hydroxide and/or diluted hydrochloric
acid may have been added to adjust pH. Each mL of AGENERASE Oral
Solution contains 46 IU vitamin E in the form of TPGS. Propylene glycol is
in the formulation to achieve adequate solubility of amprenavir. The recommended
daily dose of AGENERASE Oral Solution of 22.5 mg/kg twice daily corresponds
to a propylene glycol intake of 1,650 mg/kg/day. Acceptable intake of propylene
glycol for pharmaceuticals has not been established.
Last reviewed on RxList: 7/18/2008




Agenerase Oral Solution Drug Description
AGENERASE®
(amprenavir) Oral Solution

Because of the potential risk of toxicity from the large amount of the excipient,
propylene glycol, AGENERASE Oral Solution is contraindicated in infants and
children below the age of 4 years, pregnant women, patients with hepatic or
renal failure, and patients treated with disulfiram or metronidazole (see CONTRAINDICATIONS
AND WARNINGS). AGENERASE Oral Solution should be used only when AGENERASE
Capsules or other protease inhibitor formulations are not therapeutic options.


DRUG DESCRIPTION



What are the possible side effects of amprenavir (Agenerase)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking amprenavir and call your doctor at once if you have any of these serious side effects:

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
pale or yellowed skin, dark colored urine, fever, confusion or weakness;
increased urination or extreme thirst;
...
Read All Potential Side Effects for Agenerase Oral Solution »




AGENERASE (amprenavir) is an inhibitor of the human immunodeficiency virus
(HIV) protease. The chemical name of amprenavir is (3S)-tetrahydro-3-furyl
N-[(1S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl]carbamate.
Amprenavir is a single stereoisomer with the (3S)(1S,2R)
configuration. It has a molecular formula of C25H35N3O6S
and a molecular weight of 505.64. It has the following structural formula:








Amprenavir is a white to cream-colored solid with a solubility of approximately
0.04 mg/mL in water at 25°C.
AGENERASE Oral Solution is for oral administration. One milliliter (1
mL) of AGENERASE Oral Solution contains 15 mg of amprenavir in solution and
the inactive ingredients acesulfame potassium, artificial grape bubblegum flavor,
citric acid (anhydrous), d-alpha tocopheryl polyethylene glycol 1000 succinate
(TPGS), menthol, natural peppermint flavor, polyethylene glycol 400 (PEG 400)
(170 mg), propylene glycol (550 mg), saccharin sodium, sodium chloride, and
sodium citrate (dihydrate). Solutions of sodium hydroxide and/or diluted hydrochloric
acid may have been added to adjust pH. Each mL of AGENERASE Oral
Solution contains 46 IU vitamin E in the form of TPGS. Propylene glycol is
in the formulation to achieve adequate solubility of amprenavir. The recommended
daily dose of AGENERASE Oral Solution of 22.5 mg/kg twice daily corresponds
to a propylene glycol intake of 1,650 mg/kg/day. Acceptable intake of propylene
glycol for pharmaceuticals has not been established.
Last reviewed on RxList: 7/18/2008




Agenerase Oral Solution Drug Description
AGENERASE®
(amprenavir) Oral Solution

Because of the potential risk of toxicity from the large amount of the excipient,
propylene glycol, AGENERASE Oral Solution is contraindicated in infants and
children below the age of 4 years, pregnant women, patients with hepatic or
renal failure, and patients treated with disulfiram or metronidazole (see CONTRAINDICATIONS
AND WARNINGS). AGENERASE Oral Solution should be used only when AGENERASE
Capsules or other protease inhibitor formulations are not therapeutic options.


DRUG DESCRIPTION



What are the possible side effects of amprenavir (Agenerase)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking amprenavir and call your doctor at once if you have any of these serious side effects:

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
pale or yellowed skin, dark colored urine, fever, confusion or weakness;
increased urination or extreme thirst;
...
Read All Potential Side Effects for Agenerase Oral Solution »




AGENERASE (amprenavir) is an inhibitor of the human immunodeficiency virus
(HIV) protease. The chemical name of amprenavir is (3S)-tetrahydro-3-furyl
N-[(1S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl]carbamate.
Amprenavir is a single stereoisomer with the (3S)(1S,2R)
configuration. It has a molecular formula of C25H35N3O6S
and a molecular weight of 505.64. It has the following structural formula:








Amprenavir is a white to cream-colored solid with a solubility of approximately
0.04 mg/mL in water at 25°C.
AGENERASE Oral Solution is for oral administration. One milliliter (1
mL) of AGENERASE Oral Solution contains 15 mg of amprenavir in solution and
the inactive ingredients acesulfame potassium, artificial grape bubblegum flavor,
citric acid (anhydrous), d-alpha tocopheryl polyethylene glycol 1000 succinate
(TPGS), menthol, natural peppermint flavor, polyethylene glycol 400 (PEG 400)
(170 mg), propylene glycol (550 mg), saccharin sodium, sodium chloride, and
sodium citrate (dihydrate). Solutions of sodium hydroxide and/or diluted hydrochloric
acid may have been added to adjust pH. Each mL of AGENERASE Oral
Solution contains 46 IU vitamin E in the form of TPGS. Propylene glycol is
in the formulation to achieve adequate solubility of amprenavir. The recommended
daily dose of AGENERASE Oral Solution of 22.5 mg/kg twice daily corresponds
to a propylene glycol intake of 1,650 mg/kg/day. Acceptable intake of propylene
glycol for pharmaceuticals has not been established.
Last reviewed on RxList: 7/18/2008




Agenerase Oral Solution Drug Description
AGENERASE®
(amprenavir) Oral Solution

Because of the potential risk of toxicity from the large amount of the excipient,
propylene glycol, AGENERASE Oral Solution is contraindicated in infants and
children below the age of 4 years, pregnant women, patients with hepatic or
renal failure, and patients treated with disulfiram or metronidazole (see CONTRAINDICATIONS
AND WARNINGS). AGENERASE Oral Solution should be used only when AGENERASE
Capsules or other protease inhibitor formulations are not therapeutic options.


DRUG DESCRIPTION



What are the possible side effects of amprenavir (Agenerase)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking amprenavir and call your doctor at once if you have any of these serious side effects:

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
pale or yellowed skin, dark colored urine, fever, confusion or weakness;
increased urination or extreme thirst;
...
Read All Potential Side Effects for Agenerase Oral Solution »




AGENERASE (amprenavir) is an inhibitor of the human immunodeficiency virus
(HIV) protease. The chemical name of amprenavir is (3S)-tetrahydro-3-furyl
N-[(1S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl]carbamate.
Amprenavir is a single stereoisomer with the (3S)(1S,2R)
configuration. It has a molecular formula of C25H35N3O6S
and a molecular weight of 505.64. It has the following structural formula:








Amprenavir is a white to cream-colored solid with a solubility of approximately
0.04 mg/mL in water at 25°C.
AGENERASE Oral Solution is for oral administration. One milliliter (1
mL) of AGENERASE Oral Solution contains 15 mg of amprenavir in solution and
the inactive ingredients acesulfame potassium, artificial grape bubblegum flavor,
citric acid (anhydrous), d-alpha tocopheryl polyethylene glycol 1000 succinate
(TPGS), menthol, natural peppermint flavor, polyethylene glycol 400 (PEG 400)
(170 mg), propylene glycol (550 mg), saccharin sodium, sodium chloride, and
sodium citrate (dihydrate). Solutions of sodium hydroxide and/or diluted hydrochloric
acid may have been added to adjust pH. Each mL of AGENERASE Oral
Solution contains 46 IU vitamin E in the form of TPGS. Propylene glycol is
in the formulation to achieve adequate solubility of amprenavir. The recommended
daily dose of AGENERASE Oral Solution of 22.5 mg/kg twice daily corresponds
to a propylene glycol intake of 1,650 mg/kg/day. Acceptable intake of propylene
glycol for pharmaceuticals has not been established.
Last reviewed on RxList: 7/18/2008




Agenerase Oral Solution Drug Description
AGENERASE®
(amprenavir) Oral Solution

Because of the potential risk of toxicity from the large amount of the excipient,
propylene glycol, AGENERASE Oral Solution is contraindicated in infants and
children below the age of 4 years, pregnant women, patients with hepatic or
renal failure, and patients treated with disulfiram or metronidazole (see CONTRAINDICATIONS
AND WARNINGS). AGENERASE Oral Solution should be used only when AGENERASE
Capsules or other protease inhibitor formulations are not therapeutic options.


DRUG DESCRIPTION



What are the possible side effects of amprenavir (Agenerase)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking amprenavir and call your doctor at once if you have any of these serious side effects:

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
pale or yellowed skin, dark colored urine, fever, confusion or weakness;
increased urination or extreme thirst;
...
Read All Potential Side Effects for Agenerase Oral Solution »




AGENERASE (amprenavir) is an inhibitor of the human immunodeficiency virus
(HIV) protease. The chemical name of amprenavir is (3S)-tetrahydro-3-furyl
N-[(1S,2R)-3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl]carbamate.
Amprenavir is a single stereoisomer with the (3S)(1S,2R)
configuration. It has a molecular formula of C25H35N3O6S
and a molecular weight of 505.64. It has the following structural formula:








Amprenavir is a white to cream-colored solid with a solubility of approximately
0.04 mg/mL in water at 25°C.
AGENERASE Oral Solution is for oral administration. One milliliter (1
mL) of AGENERASE Oral Solution contains 15 mg of amprenavir in solution and
the inactive ingredients acesulfame potassium, artificial grape bubblegum flavor,
citric acid (anhydrous), d-alpha tocopheryl polyethylene glycol 1000 succinate
(TPGS), menthol, natural peppermint flavor, polyethylene glycol 400 (PEG 400)
(170 mg), propylene glycol (550 mg), saccharin sodium, sodium chloride, and
sodium citrate (dihydrate). Solutions of sodium hydroxide and/or diluted hydrochloric
acid may have been added to adjust pH. Each mL of AGENERASE Oral
Solution contains 46 IU vitamin E in the form of TPGS. Propylene glycol is
in the formulation to achieve adequate solubility of amprenavir. The recommended
daily dose of AGENERASE Oral Solution of 22.5 mg/kg twice daily corresponds
to a propylene glycol intake of 1,650 mg/kg/day. Acceptable intake of propylene
glycol for pharmaceuticals has not been established.
Last reviewed on RxList: 7/18/2008





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Other reviews about Amprenavir Oral Solution on web:

Learn about the prescription medication Agenerase Oral Solution (Amprenavir Oral Solution), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient ... Agenerase Oral Solution (Amprenavir Oral Solution) Drug ...


The amprenavir prodrug, fosamprenavir, has fewer gastrointestinal side effects. Amprenavir oral solution contains propylene glycol and should be avoided in certain patients ... Amprenavir (Agenerase)


NDA 21-039/SLR017 Page 2 PRESCRIBING INFORMATION AGENERASE ® (amprenavir) Oral Solution PATIENT INFORMATION INCLUDED Because of the potential risk of toxicity from the large ... AGENERASE® (amprenavir) Oral Solution


Consumer information about the medication AMPRENAVIR/VITAMIN E/PROPYLENE GLYCOL SOLUTION - ORAL (Agenerase), includes side effects, drug interactions, recommended dosages, and ... AMPRENAVIR/VITAMIN E/PROPYLENE GLYCOL SOLUTION - ORAL (Agenerase ...


The maximum daily dose is 2800 mg. Amprenavir capsules and solution are not interchangeable milligram for milligram. The oral solution should only be used when it is not possible ... amprenavir - HIV: Health and Medical Information About HIV and ...


Because both forms contain vitamin E, individuals who are taking either form of amprenavir should not take vitamin E supplements. Individuals who are taking the oral solution form ... AIDSinfo - HIV/AIDS Drug Information - Amprenavir


This means that it may not be safe for use during pregnancy, although the full risks are not known (see Agenerase and Pregnancy). Amprenavir oral solution (but not capsules) should ... Precautions and Warnings With Amprenavir


Learn about the prescription medication Agenerase Capsules (Amprenavir Capsules), drug ... AGENERASE Capsules should be cautioned against switching to AGENERASE Oral Solution ... Agenerase Capsules (Amprenavir Capsules) Drug Information: Uses ...


Potential safety concerns with the large amount of propylene glycol in AGENERASEĆ (amprenavir) Oral Solution. From Glaxo Wellcome: Important Drug Warning Potential safety concerns with the large amount of propylene glycol


Hemophilia—Amprenavir may make these conditions worse; Kidney failure or; Liver failure—Amprenavir oral solution should not be used because serious side effects may occur amprenavir consumer information from Drugs.com





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