Reviews Amphotericin B


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Abelcet Drug Description
ABELCET®
(amphotericin B lipid complex) Injection
DRUG DESCRIPTION
ABELCET® is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET® consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, L-α-dimyristoylphosphatidylcholine (DMPC) and L-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET® is yellow and opaque in appearance, with a pH of 5 - 7.
NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially
affect a drug's functional properties relative to those of the unencapsulated
or nonlipid-associated drug. In addition, different liposomal or lipid-complexed
products with a common active ingredient may vary from one another in the chemical
composition and physical form of the lipid component. Such differences may affect
functional properties of these drug products.
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of
Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*,
3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E,
31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxy-β-D-mannopyranosyl)
oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicy-clo[33.3.1]
nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid.
It has a molecular weight of 924.09 and a molecular formula of C47H73NO17.
The structural formula is:








ABELCET® is provided as a sterile, opaque suspension  in 20 mL glass,
single-use vials. Each 20 mL vial contains 100 mg of amphotericin B (see DOSAGE
AND ADMINISTRATION), and each mL of ABELCET® contains:
Amphotericin B USP.......................................5 mgL-α-dimyristoylphosphatidylcholine
(DMPC).......................................3.4 mg
L-α-dimyristoylphosphatidylglycerol (DMPG).......................................1.5
mg
Sodium Chloride USP.......................................9 mg
Water for Injection USP, q.s. 1 mL
Last reviewed on RxList: 4/2/2009




Abelcet Drug Description
ABELCET®
(amphotericin B lipid complex) Injection
DRUG DESCRIPTION
ABELCET® is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET® consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, L-α-dimyristoylphosphatidylcholine (DMPC) and L-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET® is yellow and opaque in appearance, with a pH of 5 - 7.
NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially
affect a drug's functional properties relative to those of the unencapsulated
or nonlipid-associated drug. In addition, different liposomal or lipid-complexed
products with a common active ingredient may vary from one another in the chemical
composition and physical form of the lipid component. Such differences may affect
functional properties of these drug products.
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of
Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*,
3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E,
31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxy-β-D-mannopyranosyl)
oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicy-clo[33.3.1]
nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid.
It has a molecular weight of 924.09 and a molecular formula of C47H73NO17.
The structural formula is:








ABELCET® is provided as a sterile, opaque suspension  in 20 mL glass,
single-use vials. Each 20 mL vial contains 100 mg of amphotericin B (see DOSAGE
AND ADMINISTRATION), and each mL of ABELCET® contains:
Amphotericin B USP.......................................5 mgL-α-dimyristoylphosphatidylcholine
(DMPC).......................................3.4 mg
L-α-dimyristoylphosphatidylglycerol (DMPG).......................................1.5
mg
Sodium Chloride USP.......................................9 mg
Water for Injection USP, q.s. 1 mL
Last reviewed on RxList: 4/2/2009




Abelcet Drug Description
ABELCET®
(amphotericin B lipid complex) Injection
DRUG DESCRIPTION
ABELCET® is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET® consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, L-α-dimyristoylphosphatidylcholine (DMPC) and L-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET® is yellow and opaque in appearance, with a pH of 5 - 7.
NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially
affect a drug's functional properties relative to those of the unencapsulated
or nonlipid-associated drug. In addition, different liposomal or lipid-complexed
products with a common active ingredient may vary from one another in the chemical
composition and physical form of the lipid component. Such differences may affect
functional properties of these drug products.
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of
Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*,
3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E,
31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxy-β-D-mannopyranosyl)
oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicy-clo[33.3.1]
nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid.
It has a molecular weight of 924.09 and a molecular formula of C47H73NO17.
The structural formula is:








ABELCET® is provided as a sterile, opaque suspension  in 20 mL glass,
single-use vials. Each 20 mL vial contains 100 mg of amphotericin B (see DOSAGE
AND ADMINISTRATION), and each mL of ABELCET® contains:
Amphotericin B USP.......................................5 mgL-α-dimyristoylphosphatidylcholine
(DMPC).......................................3.4 mg
L-α-dimyristoylphosphatidylglycerol (DMPG).......................................1.5
mg
Sodium Chloride USP.......................................9 mg
Water for Injection USP, q.s. 1 mL
Last reviewed on RxList: 4/2/2009




Abelcet Drug Description
ABELCET®
(amphotericin B lipid complex) Injection
DRUG DESCRIPTION
ABELCET® is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET® consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, L-α-dimyristoylphosphatidylcholine (DMPC) and L-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET® is yellow and opaque in appearance, with a pH of 5 - 7.
NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially
affect a drug's functional properties relative to those of the unencapsulated
or nonlipid-associated drug. In addition, different liposomal or lipid-complexed
products with a common active ingredient may vary from one another in the chemical
composition and physical form of the lipid component. Such differences may affect
functional properties of these drug products.
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of
Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*,
3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E,
31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxy-β-D-mannopyranosyl)
oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicy-clo[33.3.1]
nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid.
It has a molecular weight of 924.09 and a molecular formula of C47H73NO17.
The structural formula is:








ABELCET® is provided as a sterile, opaque suspension  in 20 mL glass,
single-use vials. Each 20 mL vial contains 100 mg of amphotericin B (see DOSAGE
AND ADMINISTRATION), and each mL of ABELCET® contains:
Amphotericin B USP.......................................5 mgL-α-dimyristoylphosphatidylcholine
(DMPC).......................................3.4 mg
L-α-dimyristoylphosphatidylglycerol (DMPG).......................................1.5
mg
Sodium Chloride USP.......................................9 mg
Water for Injection USP, q.s. 1 mL
Last reviewed on RxList: 4/2/2009




Abelcet Drug Description
ABELCET®
(amphotericin B lipid complex) Injection
DRUG DESCRIPTION
ABELCET® is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET® consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, L-α-dimyristoylphosphatidylcholine (DMPC) and L-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET® is yellow and opaque in appearance, with a pH of 5 - 7.
NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially
affect a drug's functional properties relative to those of the unencapsulated
or nonlipid-associated drug. In addition, different liposomal or lipid-complexed
products with a common active ingredient may vary from one another in the chemical
composition and physical form of the lipid component. Such differences may affect
functional properties of these drug products.
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of
Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*,
3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E,
31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxy-β-D-mannopyranosyl)
oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicy-clo[33.3.1]
nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid.
It has a molecular weight of 924.09 and a molecular formula of C47H73NO17.
The structural formula is:








ABELCET® is provided as a sterile, opaque suspension  in 20 mL glass,
single-use vials. Each 20 mL vial contains 100 mg of amphotericin B (see DOSAGE
AND ADMINISTRATION), and each mL of ABELCET® contains:
Amphotericin B USP.......................................5 mgL-α-dimyristoylphosphatidylcholine
(DMPC).......................................3.4 mg
L-α-dimyristoylphosphatidylglycerol (DMPG).......................................1.5
mg
Sodium Chloride USP.......................................9 mg
Water for Injection USP, q.s. 1 mL
Last reviewed on RxList: 4/2/2009





Other reviews about Amphotericin B on wordpress

Original article - Caspofungin versus Liposomal Amphotericin B for Empirical Antifungal Therapy in Patients with Persistent Fever and Neutropenia
  by JOC
Source: N Engl J Med Vol.351 N:14 p.1391-1402 Sep 30, 2004  Thomas J. Walsh, M.D., Hedy Teppler, M.D., Gerald R. Donowitz, M.D., Johan A. Maertens, M.D., Lindsey R. Baden, […]


UBC's global access strategy featured on CBC Radio
  by ubcuaem
Last month, CBC Radio's' The Link featured a piece on UBC's new strategy for global access to its technologies, developed in collaboration with UAEM, and the most promising current technology […]


Amphotericin B
  by gspbl20
Drug: Amphotericin B Class: Polyene antifungal Treatment For: A variety of systemic mycoses (Cryptococcus, Blastomyces, Coccidioides, Aspergillus, Histoplasma, Candida, Mucor, etc.), visceral leishmaniasis, Naegleria fowleri meningoencephalitis, and fungal meningitides (Cryptococcus, […]


UBC finalizes first global access agreement for a new therapy
  by ubcuaem
Earlier this month, UBC announced that the license agreement for Dr. Kishor Wasan's new oral formulation of anti-fungal and anti-Leishmania drug Amphotericin B has been finalized. The agreement […]


Allicin enhances the oxidative damage effect of amphotericin B against Candida albicans.
  by patoconnor
Allicin enhances the oxidative damage effect of amphotericin B against Candida albicans. An M, Shen H, Cao Y, Zhang J, Cai Y, Wang R, Jiang Y. Department of Clinical Pharmacology, […]


Lucky accidents in science
  by LeisureGuy
We know about penicillin and the vulcanization of rubber. Here's another: Kishor Wasan, a pharmacologist at the University of British Columbia, needed a negative […]


Zygomycosis and diabetes mellitus.
  by patoconnor
Zygomycosis and diabetes mellitus. Clin Microbiol Infect. 2009 Oct;15 Lanternier F, Lortholary O. Université Paris Descartes, Centre d'Infectiologie Necker-Pasteur, Service des Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants malades, Paris, France. Zygomycoses are […]


Single-Dose Liposomal Amphotericin B for Visceral Leishmaniasis in India
  by JOC
N Engl J of Medicine Feb,11, 2010  V.362 N.6 p.504-512 Shyam Sundar, M.D., Jaya Chakravarty, M.D., Dipti Agarwal, M.D., Madhukar Rai, M.D., and Henry W. Murray, M.D. ABSTRACT Background Some […]


ANTIFUNGAL CHEMOTHERAPY
  by medtextfree
ANTIFUNGAL CHEMOTHERAPY Classes of Antifungal Drugs Specific Drugs   Amphotericin B   Flucytosine   Ketoconazole   Fluconazole   Itraconazole   Clotrimazole   Griseofulvin   Miscellaneous Agents Bibliography Fungi are an important cause of human infection. Some, such as Histoplasma capsulatum and Coccidioides immitis, are indigenous to selected geographic […]


CANDIDURIA
  by medtextfree
CANDIDURIA Bibliography Confusion often accompanies a laboratory report indicating the presence of Candida or another yeast in the urine (funguria). The vexation that surrounds the detection of funguria is based […]



Other reviews about Amphotericin B on web:

Amphotericin B (Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec) is a polyene antifungal drug, often used intravenously for systemic fungal infections. Amphotericin B - Wikipedia, the free encyclopedia


Accurate, FDA approved Amphotericin B information for healthcare professionals and patients - brought to you by Drugs.com. Amphotericin B Official FDA information, side effects and uses.


Amphotericin B Wiki: Oral preparations of Amphotericin B are used to treat thrush; these are virtually nontoxic, in contrast to typical IV doses.One of the main intravenous uses is ... Amphotericin B | Amphotericin B Wiki | amphotericinb.com


All about Amphotericin B. View complete and up to date Amphotericin B information - part of the Drugs.com trusted medication database. Amphotericin B Facts and Comparisons at Drugs.com


Learn about the prescription medication Fungizone (Amphotericin B), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Fungizone (Amphotericin B) Drug Information: Uses, Side Effects ...


Amphotericin B (AMB) binds to sterols disrupting the fungal membrane, resulting in leakage and eventually cellular death. Amphotericin B deoxycholate


amphotericin B n. An antibiotic derived from strains of the actinomycete Streptomyces nodosus and used specifically in treating systemic fungal amphotericin B: Definition from Answers.com


Brand Name: AmBisome, Amphotec, Abelecet, Amphocin, Fungizone: Other Name(s): Amphotericin B lipid complex, Anfotericina B, Liposomal Amphotericin B, Mysteclin-F AIDSinfo - HIV/AIDS Drug Information - Amphotericin B


Polyenes are poly-unsaturated organic compounds that contain one or more sequences of alternating double and single carbon-carbon bonds. These double carbon-carbon bonds interact ... Amphotericin B: Facts, Discussion Forum, and Encyclopedia Article


Amphotericin B Manufacturers & Amphotericin B Suppliers Directory - Find a Amphotericin B Manufacturer and Supplier. Choose quality Amphotericin B Manufacturers, Suppliers ... Amphotericin B-Amphotericin B Manufacturers, Suppliers and ...





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