Reviews Amphotericin B


No reviews yet.

Abelcet Drug Description
ABELCET®
(amphotericin B lipid complex) Injection
DRUG DESCRIPTION
ABELCET® is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET® consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, L-α-dimyristoylphosphatidylcholine (DMPC) and L-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET® is yellow and opaque in appearance, with a pH of 5 - 7.
NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially
affect a drug's functional properties relative to those of the unencapsulated
or nonlipid-associated drug. In addition, different liposomal or lipid-complexed
products with a common active ingredient may vary from one another in the chemical
composition and physical form of the lipid component. Such differences may affect
functional properties of these drug products.
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of
Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*,
3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E,
31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxy-β-D-mannopyranosyl)
oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicy-clo[33.3.1]
nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid.
It has a molecular weight of 924.09 and a molecular formula of C47H73NO17.
The structural formula is:








ABELCET® is provided as a sterile, opaque suspension  in 20 mL glass,
single-use vials. Each 20 mL vial contains 100 mg of amphotericin B (see DOSAGE
AND ADMINISTRATION), and each mL of ABELCET® contains:
Amphotericin B USP.......................................5 mgL-α-dimyristoylphosphatidylcholine
(DMPC).......................................3.4 mg
L-α-dimyristoylphosphatidylglycerol (DMPG).......................................1.5
mg
Sodium Chloride USP.......................................9 mg
Water for Injection USP, q.s. 1 mL
Last reviewed on RxList: 4/2/2009




Abelcet Drug Description
ABELCET®
(amphotericin B lipid complex) Injection
DRUG DESCRIPTION
ABELCET® is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET® consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, L-α-dimyristoylphosphatidylcholine (DMPC) and L-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET® is yellow and opaque in appearance, with a pH of 5 - 7.
NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially
affect a drug's functional properties relative to those of the unencapsulated
or nonlipid-associated drug. In addition, different liposomal or lipid-complexed
products with a common active ingredient may vary from one another in the chemical
composition and physical form of the lipid component. Such differences may affect
functional properties of these drug products.
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of
Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*,
3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E,
31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxy-β-D-mannopyranosyl)
oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicy-clo[33.3.1]
nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid.
It has a molecular weight of 924.09 and a molecular formula of C47H73NO17.
The structural formula is:








ABELCET® is provided as a sterile, opaque suspension  in 20 mL glass,
single-use vials. Each 20 mL vial contains 100 mg of amphotericin B (see DOSAGE
AND ADMINISTRATION), and each mL of ABELCET® contains:
Amphotericin B USP.......................................5 mgL-α-dimyristoylphosphatidylcholine
(DMPC).......................................3.4 mg
L-α-dimyristoylphosphatidylglycerol (DMPG).......................................1.5
mg
Sodium Chloride USP.......................................9 mg
Water for Injection USP, q.s. 1 mL
Last reviewed on RxList: 4/2/2009




Abelcet Drug Description
ABELCET®
(amphotericin B lipid complex) Injection
DRUG DESCRIPTION
ABELCET® is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET® consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, L-α-dimyristoylphosphatidylcholine (DMPC) and L-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET® is yellow and opaque in appearance, with a pH of 5 - 7.
NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially
affect a drug's functional properties relative to those of the unencapsulated
or nonlipid-associated drug. In addition, different liposomal or lipid-complexed
products with a common active ingredient may vary from one another in the chemical
composition and physical form of the lipid component. Such differences may affect
functional properties of these drug products.
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of
Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*,
3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E,
31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxy-β-D-mannopyranosyl)
oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicy-clo[33.3.1]
nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid.
It has a molecular weight of 924.09 and a molecular formula of C47H73NO17.
The structural formula is:








ABELCET® is provided as a sterile, opaque suspension  in 20 mL glass,
single-use vials. Each 20 mL vial contains 100 mg of amphotericin B (see DOSAGE
AND ADMINISTRATION), and each mL of ABELCET® contains:
Amphotericin B USP.......................................5 mgL-α-dimyristoylphosphatidylcholine
(DMPC).......................................3.4 mg
L-α-dimyristoylphosphatidylglycerol (DMPG).......................................1.5
mg
Sodium Chloride USP.......................................9 mg
Water for Injection USP, q.s. 1 mL
Last reviewed on RxList: 4/2/2009




Abelcet Drug Description
ABELCET®
(amphotericin B lipid complex) Injection
DRUG DESCRIPTION
ABELCET® is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET® consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, L-α-dimyristoylphosphatidylcholine (DMPC) and L-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET® is yellow and opaque in appearance, with a pH of 5 - 7.
NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially
affect a drug's functional properties relative to those of the unencapsulated
or nonlipid-associated drug. In addition, different liposomal or lipid-complexed
products with a common active ingredient may vary from one another in the chemical
composition and physical form of the lipid component. Such differences may affect
functional properties of these drug products.
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of
Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*,
3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E,
31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxy-β-D-mannopyranosyl)
oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicy-clo[33.3.1]
nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid.
It has a molecular weight of 924.09 and a molecular formula of C47H73NO17.
The structural formula is:








ABELCET® is provided as a sterile, opaque suspension  in 20 mL glass,
single-use vials. Each 20 mL vial contains 100 mg of amphotericin B (see DOSAGE
AND ADMINISTRATION), and each mL of ABELCET® contains:
Amphotericin B USP.......................................5 mgL-α-dimyristoylphosphatidylcholine
(DMPC).......................................3.4 mg
L-α-dimyristoylphosphatidylglycerol (DMPG).......................................1.5
mg
Sodium Chloride USP.......................................9 mg
Water for Injection USP, q.s. 1 mL
Last reviewed on RxList: 4/2/2009




Abelcet Drug Description
ABELCET®
(amphotericin B lipid complex) Injection
DRUG DESCRIPTION
ABELCET® is a sterile, pyrogen-free suspension for intravenous infusion. ABELCET® consists of amphotericin B complexed with two phospholipids in a 1:1 drug-to-lipid molar ratio. The two phospholipids, L-α-dimyristoylphosphatidylcholine (DMPC) and L-α-dimyristoylphosphatidylglycerol (DMPG), are present in a 7:3 molar ratio. ABELCET® is yellow and opaque in appearance, with a pH of 5 - 7.
NOTE: Liposomal encapsulation or incorporation in a lipid complex can substantially
affect a drug's functional properties relative to those of the unencapsulated
or nonlipid-associated drug. In addition, different liposomal or lipid-complexed
products with a common active ingredient may vary from one another in the chemical
composition and physical form of the lipid component. Such differences may affect
functional properties of these drug products.
Amphotericin B is a polyene, antifungal antibiotic produced from a strain of
Streptomyces nodosus. Amphotericin B is designated chemically as [1R-(1R*,
3S*, 5R*, 6R*, 9R*, 11R*, 15S*, 16R*, 17R*, 18S*, 19E, 21E, 23E, 25E, 27E, 29E,
31E, 33R*, 35S*, 36R*, 37S*)]-33-[(3-Amino-3, 6-dideoxy-β-D-mannopyranosyl)
oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicy-clo[33.3.1]
nonatriaconta-19, 21, 23, 25, 27, 29, 31-heptaene-36-carboxylic acid.
It has a molecular weight of 924.09 and a molecular formula of C47H73NO17.
The structural formula is:








ABELCET® is provided as a sterile, opaque suspension  in 20 mL glass,
single-use vials. Each 20 mL vial contains 100 mg of amphotericin B (see DOSAGE
AND ADMINISTRATION), and each mL of ABELCET® contains:
Amphotericin B USP.......................................5 mgL-α-dimyristoylphosphatidylcholine
(DMPC).......................................3.4 mg
L-α-dimyristoylphosphatidylglycerol (DMPG).......................................1.5
mg
Sodium Chloride USP.......................................9 mg
Water for Injection USP, q.s. 1 mL
Last reviewed on RxList: 4/2/2009





Other reviews about Amphotericin B on wordpress

Original article - Caspofungin versus Liposomal Amphotericin B for Empirical Antifungal Therapy in Patients with Persistent Fever and Neutropenia
  by JOC
Source: N Engl J Med Vol.351 N:14 p.1391-1402 Sep 30, 2004¬† Thomas J. Walsh, M.D., Hedy Teppler, M.D., Gerald R. Donowitz, M.D., Johan A. Maertens, M.D., Lindsey R. Baden, […]


UBC's global access strategy featured on CBC Radio
  by ubcuaem
Last month,¬†CBC Radio's' The Link featured a piece on UBC's new strategy for global access to its technologies, developed in collaboration with UAEM,¬†and the most promising current technology […]


Amphotericin B
  by gspbl20
Drug: Amphotericin B Class: Polyene antifungal Treatment For: A variety of systemic mycoses (Cryptococcus, Blastomyces, Coccidioides, Aspergillus, Histoplasma, Candida, Mucor, etc.), visceral leishmaniasis, Naegleria fowleri meningoencephalitis, and fungal meningitides (Cryptococcus, […]


UBC finalizes first global access agreement for a new therapy
  by ubcuaem
Earlier this month, UBC announced that the license agreement for Dr. Kishor Wasan's new oral formulation of anti-fungal and anti-Leishmania drug Amphotericin B has been finalized. The agreement […]


Allicin enhances the oxidative damage effect of amphotericin B against Candida albicans.
  by patoconnor
Allicin enhances the oxidative damage effect of amphotericin B against Candida albicans. An M, Shen H, Cao Y, Zhang J, Cai Y, Wang R, Jiang Y. Department of Clinical Pharmacology, […]


Lucky accidents in science
  by LeisureGuy
We know about penicillin and the vulcanization of rubber. Here's another: Kishor Wasan, a pharmacologist at the University of British Columbia, needed a negative […]


Zygomycosis and diabetes mellitus.
  by patoconnor
Zygomycosis and diabetes mellitus. Clin Microbiol Infect. 2009 Oct;15 Lanternier F, Lortholary O. Universit√© Paris Descartes, Centre d'Infectiologie Necker-Pasteur, Service des Maladies Infectieuses et Tropicales, H√īpital Necker-Enfants malades, Paris, France. Zygomycoses are […]


Single-Dose Liposomal Amphotericin B for Visceral Leishmaniasis in India
  by JOC
N Engl J of Medicine Feb,11, 2010¬† V.362 N.6 p.504-512 Shyam Sundar, M.D., Jaya Chakravarty, M.D., Dipti Agarwal, M.D., Madhukar Rai, M.D., and Henry W. Murray, M.D. ABSTRACT Background Some […]


ANTIFUNGAL CHEMOTHERAPY
  by medtextfree
ANTIFUNGAL CHEMOTHERAPY Classes of Antifungal Drugs Specific Drugs ¬† Amphotericin B ¬† Flucytosine ¬† Ketoconazole ¬† Fluconazole ¬† Itraconazole ¬† Clotrimazole ¬† Griseofulvin ¬† Miscellaneous Agents Bibliography Fungi are an important cause of human infection. Some, such as Histoplasma capsulatum and Coccidioides immitis, are indigenous to selected geographic […]


CANDIDURIA
  by medtextfree
CANDIDURIA Bibliography Confusion often accompanies a laboratory report indicating the presence of Candida or another yeast in the urine (funguria). The vexation that surrounds the detection of funguria is based […]



Other reviews about Amphotericin B on web:

Amphotericin B (Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec) is a polyene antifungal drug, often used intravenously for systemic fungal infections. Amphotericin B - Wikipedia, the free encyclopedia


Accurate, FDA approved Amphotericin B information for healthcare professionals and patients - brought to you by Drugs.com. Amphotericin B Official FDA information, side effects and uses.


Amphotericin B Wiki: Oral preparations of Amphotericin B are used to treat thrush; these are virtually nontoxic, in contrast to typical IV doses.One of the main intravenous uses is ... Amphotericin B | Amphotericin B Wiki | amphotericinb.com


All about Amphotericin B. View complete and up to date Amphotericin B information - part of the Drugs.com trusted medication database. Amphotericin B Facts and Comparisons at Drugs.com


Learn about the prescription medication Fungizone (Amphotericin B), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Fungizone (Amphotericin B) Drug Information: Uses, Side Effects ...


Amphotericin B (AMB) binds to sterols disrupting the fungal membrane, resulting in leakage and eventually cellular death. Amphotericin B deoxycholate


amphotericin B n. An antibiotic derived from strains of the actinomycete Streptomyces nodosus and used specifically in treating systemic fungal amphotericin B: Definition from Answers.com


Brand Name: AmBisome, Amphotec, Abelecet, Amphocin, Fungizone: Other Name(s): Amphotericin B lipid complex, Anfotericina B, Liposomal Amphotericin B, Mysteclin-F AIDSinfo - HIV/AIDS Drug Information - Amphotericin B


Polyenes are poly-unsaturated organic compounds that contain one or more sequences of alternating double and single carbon-carbon bonds. These double carbon-carbon bonds interact ... Amphotericin B: Facts, Discussion Forum, and Encyclopedia Article


Amphotericin B Manufacturers & Amphotericin B Suppliers Directory - Find a Amphotericin B Manufacturer and Supplier. Choose quality Amphotericin B Manufacturers, Suppliers ... Amphotericin B-Amphotericin B Manufacturers, Suppliers and ...





Featured Reviews

Reviews Dutasteride

Avodart Drug Description AVODART (dutasteride) Soft Gelatin Capsules DRUG DESCRIPTION What are the possible side effects of dutasteride (Avodart)? Get emergency medical help if you have any of these signs of an allergic reaction:...
Read More  |  Review This
Reviews Elestat

Elestat Drug Description ELESTAT® (epinastine HCl) Ophthalmic Solution 0.05% Sterile DRUG DESCRIPTION What are the possible side effects of epinastine ophthalmic (Elestat)? Serious side effects are not expected to occur with...
Read More  |  Review This
Reviews rDNA origin)

Serostim Drug Description Serostim® [somatropin (rDNA origin) for injection] DRUG DESCRIPTION What are the possible side effects of somatropin? If you have Prader-Willi syndrome, call your doctor promptly if you develop signs...
Read More  |  Review This
Reviews Etanercept

Enbrel Drug Description Enbrel (etanercept) Solution for Subcutaneous Use WARNINGS SERIOUS INFECTIONS AND MALIGNANCIES SERIOUS INFECTIONS Patients treated with Enbrel are at increased risk for developing serious infections that may...
Read More  |  Review This
Reviews Norvasc

Norvasc Drug Description NORVASC® (amlodipine besylate) Tablets for Oral Administration DRUG DESCRIPTION What are the possible side effects of amlodipine (Norvasc)? Get emergency medical help if you have any of these signs...
Read More  |  Review This
Recent News
59sec - the BEST lead management system around!
We tested 59sec - THE lead management system and we love it. 59sec helps small and medium companies to answer leads in maximum 59 seconds. Why...
MOVEorPAY - our favorite facebook app
We do love MOVEorPAY motivational facebook app, because it is very cool and useful. It makes you finish stuff that you know are good for you, but from various reasons, you never do...
ReviewsAZ is almost ready to be officially launched
yes, we have just a few loose ends to tie and we are ready to go :) meanwhile, I am putting some reviews on the site, so people will not get an empty site at the launch....