Reviews Amlodipine Besylate and Benazepril HCl


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Lotrel Drug Description
Lotrel
(amlodipine besylate and benazepril hydrochloride) Capsules

WARNING
AVOID USE IN PREGNANCY
When pregnancy is detected, discontinue Lotrel as soon as possible. Drugs that
act directly on the renin-angiotensin system can cause injury and death to the
developing fetus (5.4)

DRUG DESCRIPTION



What are the possible side effects of amlodipine and benazepril (Lotrel)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Some side effects of amlodipine and benazepril may not occur until after you have been using the medication for several months.
Call your doctor at once if you have any of these serious side effects:

feeling...
Read All Potential Side Effects for Lotrel »




Lotrel is a combination of amlodipine besylate and benazepril hydrochloride.
Benazepril hydrochloride is a white to off-white crystalline powder, soluble
( > 100 mg/mL) in water, in ethanol, and in methanol. Benazepril hydrochloride's
chemical name is 3-[[1-(ethoxycarbonyl)-3-phenyl-(1S)propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic
acid monohydrochloride; its structural formula is








Its empirical formula is C24H28N2O5•HCl,
and its molecular weight is 460.96.
Benazeprilat, the active metabolite of benazepril, is a nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Benazepril is converted to benazeprilat by hepatic cleavage
of the ester group.
Amlodipine besylate is a white to pale yellow crystalline powder, slightly
soluble in water and sparingly soluble in ethanol. Its chemical name is (R,S)3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4dihydro-6-methyl-3,5-pyridinedicarboxylate
benzenesulfonate; its structural formula is








Its empirical formula is C20H25ClN2O5•C6H6O3S,
and its molecular weight is 567.1. Amlodipine besylate is the besylate salt
of amlodipine, a dihydropyridine calcium channel blocker. Lotrel capsules are
formulated in six different strengths for oral administration with a combination
of amlodipine besylate equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine, with
10 mg, 20 mg or 40 mg of benazepril hydrochloride providing for the following
available combinations: 2.5/10 mg, 5/10 mg, 5/20 mg, 5/40 mg, 10/20 mg and 10/40
mg.
The inactive ingredients of the capsules are calcium phosphate, cellulose compounds,
colloidal silicon dioxide, crospovidone, gelatin, hydrogenated castor oil (not
present in 5/40 mg or 10/40 mg strengths), iron oxides, lactose, magnesium stearate,
polysorbate 80, silicon dioxide, sodium lauryl sulfate, sodium starch (potato)
glycolate, starch (corn), talc, and titanium dioxide.
Last reviewed on RxList: 4/16/2010




Lotrel Drug Description
Lotrel
(amlodipine besylate and benazepril hydrochloride) Capsules

WARNING
AVOID USE IN PREGNANCY
When pregnancy is detected, discontinue Lotrel as soon as possible. Drugs that
act directly on the renin-angiotensin system can cause injury and death to the
developing fetus (5.4)

DRUG DESCRIPTION



What are the possible side effects of amlodipine and benazepril (Lotrel)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Some side effects of amlodipine and benazepril may not occur until after you have been using the medication for several months.
Call your doctor at once if you have any of these serious side effects:

feeling...
Read All Potential Side Effects for Lotrel »




Lotrel is a combination of amlodipine besylate and benazepril hydrochloride.
Benazepril hydrochloride is a white to off-white crystalline powder, soluble
( > 100 mg/mL) in water, in ethanol, and in methanol. Benazepril hydrochloride's
chemical name is 3-[[1-(ethoxycarbonyl)-3-phenyl-(1S)propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic
acid monohydrochloride; its structural formula is








Its empirical formula is C24H28N2O5•HCl,
and its molecular weight is 460.96.
Benazeprilat, the active metabolite of benazepril, is a nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Benazepril is converted to benazeprilat by hepatic cleavage
of the ester group.
Amlodipine besylate is a white to pale yellow crystalline powder, slightly
soluble in water and sparingly soluble in ethanol. Its chemical name is (R,S)3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4dihydro-6-methyl-3,5-pyridinedicarboxylate
benzenesulfonate; its structural formula is








Its empirical formula is C20H25ClN2O5•C6H6O3S,
and its molecular weight is 567.1. Amlodipine besylate is the besylate salt
of amlodipine, a dihydropyridine calcium channel blocker. Lotrel capsules are
formulated in six different strengths for oral administration with a combination
of amlodipine besylate equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine, with
10 mg, 20 mg or 40 mg of benazepril hydrochloride providing for the following
available combinations: 2.5/10 mg, 5/10 mg, 5/20 mg, 5/40 mg, 10/20 mg and 10/40
mg.
The inactive ingredients of the capsules are calcium phosphate, cellulose compounds,
colloidal silicon dioxide, crospovidone, gelatin, hydrogenated castor oil (not
present in 5/40 mg or 10/40 mg strengths), iron oxides, lactose, magnesium stearate,
polysorbate 80, silicon dioxide, sodium lauryl sulfate, sodium starch (potato)
glycolate, starch (corn), talc, and titanium dioxide.
Last reviewed on RxList: 4/16/2010




Lotrel Drug Description
Lotrel
(amlodipine besylate and benazepril hydrochloride) Capsules

WARNING
AVOID USE IN PREGNANCY
When pregnancy is detected, discontinue Lotrel as soon as possible. Drugs that
act directly on the renin-angiotensin system can cause injury and death to the
developing fetus (5.4)

DRUG DESCRIPTION



What are the possible side effects of amlodipine and benazepril (Lotrel)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Some side effects of amlodipine and benazepril may not occur until after you have been using the medication for several months.
Call your doctor at once if you have any of these serious side effects:

feeling...
Read All Potential Side Effects for Lotrel »




Lotrel is a combination of amlodipine besylate and benazepril hydrochloride.
Benazepril hydrochloride is a white to off-white crystalline powder, soluble
( > 100 mg/mL) in water, in ethanol, and in methanol. Benazepril hydrochloride's
chemical name is 3-[[1-(ethoxycarbonyl)-3-phenyl-(1S)propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic
acid monohydrochloride; its structural formula is








Its empirical formula is C24H28N2O5•HCl,
and its molecular weight is 460.96.
Benazeprilat, the active metabolite of benazepril, is a nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Benazepril is converted to benazeprilat by hepatic cleavage
of the ester group.
Amlodipine besylate is a white to pale yellow crystalline powder, slightly
soluble in water and sparingly soluble in ethanol. Its chemical name is (R,S)3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4dihydro-6-methyl-3,5-pyridinedicarboxylate
benzenesulfonate; its structural formula is








Its empirical formula is C20H25ClN2O5•C6H6O3S,
and its molecular weight is 567.1. Amlodipine besylate is the besylate salt
of amlodipine, a dihydropyridine calcium channel blocker. Lotrel capsules are
formulated in six different strengths for oral administration with a combination
of amlodipine besylate equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine, with
10 mg, 20 mg or 40 mg of benazepril hydrochloride providing for the following
available combinations: 2.5/10 mg, 5/10 mg, 5/20 mg, 5/40 mg, 10/20 mg and 10/40
mg.
The inactive ingredients of the capsules are calcium phosphate, cellulose compounds,
colloidal silicon dioxide, crospovidone, gelatin, hydrogenated castor oil (not
present in 5/40 mg or 10/40 mg strengths), iron oxides, lactose, magnesium stearate,
polysorbate 80, silicon dioxide, sodium lauryl sulfate, sodium starch (potato)
glycolate, starch (corn), talc, and titanium dioxide.
Last reviewed on RxList: 4/16/2010




Lotrel Drug Description
Lotrel
(amlodipine besylate and benazepril hydrochloride) Capsules

WARNING
AVOID USE IN PREGNANCY
When pregnancy is detected, discontinue Lotrel as soon as possible. Drugs that
act directly on the renin-angiotensin system can cause injury and death to the
developing fetus (5.4)

DRUG DESCRIPTION



What are the possible side effects of amlodipine and benazepril (Lotrel)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Some side effects of amlodipine and benazepril may not occur until after you have been using the medication for several months.
Call your doctor at once if you have any of these serious side effects:

feeling...
Read All Potential Side Effects for Lotrel »




Lotrel is a combination of amlodipine besylate and benazepril hydrochloride.
Benazepril hydrochloride is a white to off-white crystalline powder, soluble
( > 100 mg/mL) in water, in ethanol, and in methanol. Benazepril hydrochloride's
chemical name is 3-[[1-(ethoxycarbonyl)-3-phenyl-(1S)propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic
acid monohydrochloride; its structural formula is








Its empirical formula is C24H28N2O5•HCl,
and its molecular weight is 460.96.
Benazeprilat, the active metabolite of benazepril, is a nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Benazepril is converted to benazeprilat by hepatic cleavage
of the ester group.
Amlodipine besylate is a white to pale yellow crystalline powder, slightly
soluble in water and sparingly soluble in ethanol. Its chemical name is (R,S)3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4dihydro-6-methyl-3,5-pyridinedicarboxylate
benzenesulfonate; its structural formula is








Its empirical formula is C20H25ClN2O5•C6H6O3S,
and its molecular weight is 567.1. Amlodipine besylate is the besylate salt
of amlodipine, a dihydropyridine calcium channel blocker. Lotrel capsules are
formulated in six different strengths for oral administration with a combination
of amlodipine besylate equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine, with
10 mg, 20 mg or 40 mg of benazepril hydrochloride providing for the following
available combinations: 2.5/10 mg, 5/10 mg, 5/20 mg, 5/40 mg, 10/20 mg and 10/40
mg.
The inactive ingredients of the capsules are calcium phosphate, cellulose compounds,
colloidal silicon dioxide, crospovidone, gelatin, hydrogenated castor oil (not
present in 5/40 mg or 10/40 mg strengths), iron oxides, lactose, magnesium stearate,
polysorbate 80, silicon dioxide, sodium lauryl sulfate, sodium starch (potato)
glycolate, starch (corn), talc, and titanium dioxide.
Last reviewed on RxList: 4/16/2010




Lotrel Drug Description
Lotrel
(amlodipine besylate and benazepril hydrochloride) Capsules

WARNING
AVOID USE IN PREGNANCY
When pregnancy is detected, discontinue Lotrel as soon as possible. Drugs that
act directly on the renin-angiotensin system can cause injury and death to the
developing fetus (5.4)

DRUG DESCRIPTION



What are the possible side effects of amlodipine and benazepril (Lotrel)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Some side effects of amlodipine and benazepril may not occur until after you have been using the medication for several months.
Call your doctor at once if you have any of these serious side effects:

feeling...
Read All Potential Side Effects for Lotrel »




Lotrel is a combination of amlodipine besylate and benazepril hydrochloride.
Benazepril hydrochloride is a white to off-white crystalline powder, soluble
( > 100 mg/mL) in water, in ethanol, and in methanol. Benazepril hydrochloride's
chemical name is 3-[[1-(ethoxycarbonyl)-3-phenyl-(1S)propyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-(3S)-benzazepine-1-acetic
acid monohydrochloride; its structural formula is








Its empirical formula is C24H28N2O5•HCl,
and its molecular weight is 460.96.
Benazeprilat, the active metabolite of benazepril, is a nonsulfhydryl angiotensin-converting enzyme (ACE) inhibitor. Benazepril is converted to benazeprilat by hepatic cleavage
of the ester group.
Amlodipine besylate is a white to pale yellow crystalline powder, slightly
soluble in water and sparingly soluble in ethanol. Its chemical name is (R,S)3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-1,4dihydro-6-methyl-3,5-pyridinedicarboxylate
benzenesulfonate; its structural formula is








Its empirical formula is C20H25ClN2O5•C6H6O3S,
and its molecular weight is 567.1. Amlodipine besylate is the besylate salt
of amlodipine, a dihydropyridine calcium channel blocker. Lotrel capsules are
formulated in six different strengths for oral administration with a combination
of amlodipine besylate equivalent to 2.5 mg, 5 mg or 10 mg of amlodipine, with
10 mg, 20 mg or 40 mg of benazepril hydrochloride providing for the following
available combinations: 2.5/10 mg, 5/10 mg, 5/20 mg, 5/40 mg, 10/20 mg and 10/40
mg.
The inactive ingredients of the capsules are calcium phosphate, cellulose compounds,
colloidal silicon dioxide, crospovidone, gelatin, hydrogenated castor oil (not
present in 5/40 mg or 10/40 mg strengths), iron oxides, lactose, magnesium stearate,
polysorbate 80, silicon dioxide, sodium lauryl sulfate, sodium starch (potato)
glycolate, starch (corn), talc, and titanium dioxide.
Last reviewed on RxList: 4/16/2010





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Other reviews about Amlodipine Besylate and Benazepril HCl on web:

Learn about the prescription medication Lotrel (Amlodipine Besylate and Benazepril HCl), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Lotrel (Amlodipine Besylate and Benazepril HCl) Drug Information ...


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