Reviews Alpha-Proteinase Inhibitor


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Zemaira Drug Description
ZEMAIRA™
ALPHA1-PROTEINASE INHIBITOR (HUMAN)
AVENTIS BEHRING L.L.C. Kankakee,Illinois 60901,U.S.A.
DRUG DESCRIPTION



What are the possible side effects of alpha 1-proteinase inhibitor (Aralast, Aralast NP, Prolastin, Zemaira)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficulty breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

chest pain, severe headache, buzzing in your ears, uneven heartbeats;
fast heart rate;
problems with vision; or
fever, chills, runny nose,...
Read All Potential Side Effects for Zemaira »



Alpha1-Proteinase Inhibitor (Human), Zemaira™, is a sterile, stable, lyophilized preparation of highly purified human alpha1-proteinase inhibitor (A1-PI), also known as alpha1-antitrypsin, derived from human plasma. Zemaira™ is manufactured from large pools of human plasma by cold ethanol fractionation according to a modified Cohn process followed by additional purification steps. Zemaira™ is supplied as a sterile, white, lyophilized powder to be administered by the intravenous route. The specific activity of Zemaira™ is ≥0.7 mg of functional A1-PI per milligram of total protein. The purity is ≥90% A1-PI. Following reconstitution with 20 mL of Sterile Water for Injection, U.S.P., each vial contains approximately 1000 mg of functionally active A1-PI, 81 mM sodium, 38 mM chloride, 17 mM phosphate, and 144 mM mannitol. Hydrochloric acid and/or sodium hydroxide may have been added to adjust the pH. Zemaira™ contains no preservatives. Each vial of Zemaira™ contains the labeled amount of functionally active A1-PI in milligrams as stated on the vial label as determined by its capacity to neutralize human neutrophil elastase. The plasma used in the manufacture of this product has been tested and found to be nonreactive to HBsAg, nonreactive for antibody to Hepatitis C Virus (Anti-HCV), and negative for antibody to Human Immunodeficiency Virus (Anti-HIV-1/HIV-2). Two viral reduction steps are employed in the manufacture of Zemaira™: pasteurization at 60°C for 10 hours in an aqueous solution with stabilizers and two sequential ultrafiltration steps. These viral reduction steps have been validated in a series of in vitro experiments for their capacity to inactivate/remove Human Immunodeficiency Virus (HIV), Hepatitis A Virus (HAV), and the following model viruses: Bovine Viral Diarrhea Virus (BVDV) as a model virus for HCV, Canine Parvovirus (CPV) as a model virus for Parvovirus B19, and Pseudorabies Virus (PRV) as a nonspecific model virus to cover a wide range of physiochemical properties of the viruses studied. Total mean log10 reductions range from 6.8 to >12.2 log10 as shown in Table 1. Table 1: Mean (cumulative) virus reduction factors   Mean Reduction Factor Mean Reduction Factor Cumulative Reduction   Pasteurization Two Ultrafiltration Factor [log10]   [log10] Steps [log10]   HIV-1 ≥ 6.7 ≥ 5.5 ≥ 12.2 BVDV ≥ 5.9 5.1 ≥ 11.0 PRV 4.3 ≥ 6.9 ≥ 11.2 HAV ≥ 5.4 ≥ 6.3 ≥ 11.7 CPV (0.9) 6.8 6.8 Last reviewed on RxList: 12/8/2004




Zemaira Drug Description
ZEMAIRA™
ALPHA1-PROTEINASE INHIBITOR (HUMAN)
AVENTIS BEHRING L.L.C. Kankakee,Illinois 60901,U.S.A.
DRUG DESCRIPTION



What are the possible side effects of alpha 1-proteinase inhibitor (Aralast, Aralast NP, Prolastin, Zemaira)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficulty breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

chest pain, severe headache, buzzing in your ears, uneven heartbeats;
fast heart rate;
problems with vision; or
fever, chills, runny nose,...
Read All Potential Side Effects for Zemaira »



Alpha1-Proteinase Inhibitor (Human), Zemaira™, is a sterile, stable, lyophilized preparation of highly purified human alpha1-proteinase inhibitor (A1-PI), also known as alpha1-antitrypsin, derived from human plasma. Zemaira™ is manufactured from large pools of human plasma by cold ethanol fractionation according to a modified Cohn process followed by additional purification steps. Zemaira™ is supplied as a sterile, white, lyophilized powder to be administered by the intravenous route. The specific activity of Zemaira™ is ≥0.7 mg of functional A1-PI per milligram of total protein. The purity is ≥90% A1-PI. Following reconstitution with 20 mL of Sterile Water for Injection, U.S.P., each vial contains approximately 1000 mg of functionally active A1-PI, 81 mM sodium, 38 mM chloride, 17 mM phosphate, and 144 mM mannitol. Hydrochloric acid and/or sodium hydroxide may have been added to adjust the pH. Zemaira™ contains no preservatives. Each vial of Zemaira™ contains the labeled amount of functionally active A1-PI in milligrams as stated on the vial label as determined by its capacity to neutralize human neutrophil elastase. The plasma used in the manufacture of this product has been tested and found to be nonreactive to HBsAg, nonreactive for antibody to Hepatitis C Virus (Anti-HCV), and negative for antibody to Human Immunodeficiency Virus (Anti-HIV-1/HIV-2). Two viral reduction steps are employed in the manufacture of Zemaira™: pasteurization at 60°C for 10 hours in an aqueous solution with stabilizers and two sequential ultrafiltration steps. These viral reduction steps have been validated in a series of in vitro experiments for their capacity to inactivate/remove Human Immunodeficiency Virus (HIV), Hepatitis A Virus (HAV), and the following model viruses: Bovine Viral Diarrhea Virus (BVDV) as a model virus for HCV, Canine Parvovirus (CPV) as a model virus for Parvovirus B19, and Pseudorabies Virus (PRV) as a nonspecific model virus to cover a wide range of physiochemical properties of the viruses studied. Total mean log10 reductions range from 6.8 to >12.2 log10 as shown in Table 1. Table 1: Mean (cumulative) virus reduction factors   Mean Reduction Factor Mean Reduction Factor Cumulative Reduction   Pasteurization Two Ultrafiltration Factor [log10]   [log10] Steps [log10]   HIV-1 ≥ 6.7 ≥ 5.5 ≥ 12.2 BVDV ≥ 5.9 5.1 ≥ 11.0 PRV 4.3 ≥ 6.9 ≥ 11.2 HAV ≥ 5.4 ≥ 6.3 ≥ 11.7 CPV (0.9) 6.8 6.8 Last reviewed on RxList: 12/8/2004




Zemaira Drug Description
ZEMAIRA™
ALPHA1-PROTEINASE INHIBITOR (HUMAN)
AVENTIS BEHRING L.L.C. Kankakee,Illinois 60901,U.S.A.
DRUG DESCRIPTION



What are the possible side effects of alpha 1-proteinase inhibitor (Aralast, Aralast NP, Prolastin, Zemaira)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficulty breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

chest pain, severe headache, buzzing in your ears, uneven heartbeats;
fast heart rate;
problems with vision; or
fever, chills, runny nose,...
Read All Potential Side Effects for Zemaira »



Alpha1-Proteinase Inhibitor (Human), Zemaira™, is a sterile, stable, lyophilized preparation of highly purified human alpha1-proteinase inhibitor (A1-PI), also known as alpha1-antitrypsin, derived from human plasma. Zemaira™ is manufactured from large pools of human plasma by cold ethanol fractionation according to a modified Cohn process followed by additional purification steps. Zemaira™ is supplied as a sterile, white, lyophilized powder to be administered by the intravenous route. The specific activity of Zemaira™ is ≥0.7 mg of functional A1-PI per milligram of total protein. The purity is ≥90% A1-PI. Following reconstitution with 20 mL of Sterile Water for Injection, U.S.P., each vial contains approximately 1000 mg of functionally active A1-PI, 81 mM sodium, 38 mM chloride, 17 mM phosphate, and 144 mM mannitol. Hydrochloric acid and/or sodium hydroxide may have been added to adjust the pH. Zemaira™ contains no preservatives. Each vial of Zemaira™ contains the labeled amount of functionally active A1-PI in milligrams as stated on the vial label as determined by its capacity to neutralize human neutrophil elastase. The plasma used in the manufacture of this product has been tested and found to be nonreactive to HBsAg, nonreactive for antibody to Hepatitis C Virus (Anti-HCV), and negative for antibody to Human Immunodeficiency Virus (Anti-HIV-1/HIV-2). Two viral reduction steps are employed in the manufacture of Zemaira™: pasteurization at 60°C for 10 hours in an aqueous solution with stabilizers and two sequential ultrafiltration steps. These viral reduction steps have been validated in a series of in vitro experiments for their capacity to inactivate/remove Human Immunodeficiency Virus (HIV), Hepatitis A Virus (HAV), and the following model viruses: Bovine Viral Diarrhea Virus (BVDV) as a model virus for HCV, Canine Parvovirus (CPV) as a model virus for Parvovirus B19, and Pseudorabies Virus (PRV) as a nonspecific model virus to cover a wide range of physiochemical properties of the viruses studied. Total mean log10 reductions range from 6.8 to >12.2 log10 as shown in Table 1. Table 1: Mean (cumulative) virus reduction factors   Mean Reduction Factor Mean Reduction Factor Cumulative Reduction   Pasteurization Two Ultrafiltration Factor [log10]   [log10] Steps [log10]   HIV-1 ≥ 6.7 ≥ 5.5 ≥ 12.2 BVDV ≥ 5.9 5.1 ≥ 11.0 PRV 4.3 ≥ 6.9 ≥ 11.2 HAV ≥ 5.4 ≥ 6.3 ≥ 11.7 CPV (0.9) 6.8 6.8 Last reviewed on RxList: 12/8/2004




Zemaira Drug Description
ZEMAIRA™
ALPHA1-PROTEINASE INHIBITOR (HUMAN)
AVENTIS BEHRING L.L.C. Kankakee,Illinois 60901,U.S.A.
DRUG DESCRIPTION



What are the possible side effects of alpha 1-proteinase inhibitor (Aralast, Aralast NP, Prolastin, Zemaira)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficulty breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

chest pain, severe headache, buzzing in your ears, uneven heartbeats;
fast heart rate;
problems with vision; or
fever, chills, runny nose,...
Read All Potential Side Effects for Zemaira »



Alpha1-Proteinase Inhibitor (Human), Zemaira™, is a sterile, stable, lyophilized preparation of highly purified human alpha1-proteinase inhibitor (A1-PI), also known as alpha1-antitrypsin, derived from human plasma. Zemaira™ is manufactured from large pools of human plasma by cold ethanol fractionation according to a modified Cohn process followed by additional purification steps. Zemaira™ is supplied as a sterile, white, lyophilized powder to be administered by the intravenous route. The specific activity of Zemaira™ is ≥0.7 mg of functional A1-PI per milligram of total protein. The purity is ≥90% A1-PI. Following reconstitution with 20 mL of Sterile Water for Injection, U.S.P., each vial contains approximately 1000 mg of functionally active A1-PI, 81 mM sodium, 38 mM chloride, 17 mM phosphate, and 144 mM mannitol. Hydrochloric acid and/or sodium hydroxide may have been added to adjust the pH. Zemaira™ contains no preservatives. Each vial of Zemaira™ contains the labeled amount of functionally active A1-PI in milligrams as stated on the vial label as determined by its capacity to neutralize human neutrophil elastase. The plasma used in the manufacture of this product has been tested and found to be nonreactive to HBsAg, nonreactive for antibody to Hepatitis C Virus (Anti-HCV), and negative for antibody to Human Immunodeficiency Virus (Anti-HIV-1/HIV-2). Two viral reduction steps are employed in the manufacture of Zemaira™: pasteurization at 60°C for 10 hours in an aqueous solution with stabilizers and two sequential ultrafiltration steps. These viral reduction steps have been validated in a series of in vitro experiments for their capacity to inactivate/remove Human Immunodeficiency Virus (HIV), Hepatitis A Virus (HAV), and the following model viruses: Bovine Viral Diarrhea Virus (BVDV) as a model virus for HCV, Canine Parvovirus (CPV) as a model virus for Parvovirus B19, and Pseudorabies Virus (PRV) as a nonspecific model virus to cover a wide range of physiochemical properties of the viruses studied. Total mean log10 reductions range from 6.8 to >12.2 log10 as shown in Table 1. Table 1: Mean (cumulative) virus reduction factors   Mean Reduction Factor Mean Reduction Factor Cumulative Reduction   Pasteurization Two Ultrafiltration Factor [log10]   [log10] Steps [log10]   HIV-1 ≥ 6.7 ≥ 5.5 ≥ 12.2 BVDV ≥ 5.9 5.1 ≥ 11.0 PRV 4.3 ≥ 6.9 ≥ 11.2 HAV ≥ 5.4 ≥ 6.3 ≥ 11.7 CPV (0.9) 6.8 6.8 Last reviewed on RxList: 12/8/2004




Zemaira Drug Description
ZEMAIRA™
ALPHA1-PROTEINASE INHIBITOR (HUMAN)
AVENTIS BEHRING L.L.C. Kankakee,Illinois 60901,U.S.A.
DRUG DESCRIPTION



What are the possible side effects of alpha 1-proteinase inhibitor (Aralast, Aralast NP, Prolastin, Zemaira)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficulty breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:

chest pain, severe headache, buzzing in your ears, uneven heartbeats;
fast heart rate;
problems with vision; or
fever, chills, runny nose,...
Read All Potential Side Effects for Zemaira »



Alpha1-Proteinase Inhibitor (Human), Zemaira™, is a sterile, stable, lyophilized preparation of highly purified human alpha1-proteinase inhibitor (A1-PI), also known as alpha1-antitrypsin, derived from human plasma. Zemaira™ is manufactured from large pools of human plasma by cold ethanol fractionation according to a modified Cohn process followed by additional purification steps. Zemaira™ is supplied as a sterile, white, lyophilized powder to be administered by the intravenous route. The specific activity of Zemaira™ is ≥0.7 mg of functional A1-PI per milligram of total protein. The purity is ≥90% A1-PI. Following reconstitution with 20 mL of Sterile Water for Injection, U.S.P., each vial contains approximately 1000 mg of functionally active A1-PI, 81 mM sodium, 38 mM chloride, 17 mM phosphate, and 144 mM mannitol. Hydrochloric acid and/or sodium hydroxide may have been added to adjust the pH. Zemaira™ contains no preservatives. Each vial of Zemaira™ contains the labeled amount of functionally active A1-PI in milligrams as stated on the vial label as determined by its capacity to neutralize human neutrophil elastase. The plasma used in the manufacture of this product has been tested and found to be nonreactive to HBsAg, nonreactive for antibody to Hepatitis C Virus (Anti-HCV), and negative for antibody to Human Immunodeficiency Virus (Anti-HIV-1/HIV-2). Two viral reduction steps are employed in the manufacture of Zemaira™: pasteurization at 60°C for 10 hours in an aqueous solution with stabilizers and two sequential ultrafiltration steps. These viral reduction steps have been validated in a series of in vitro experiments for their capacity to inactivate/remove Human Immunodeficiency Virus (HIV), Hepatitis A Virus (HAV), and the following model viruses: Bovine Viral Diarrhea Virus (BVDV) as a model virus for HCV, Canine Parvovirus (CPV) as a model virus for Parvovirus B19, and Pseudorabies Virus (PRV) as a nonspecific model virus to cover a wide range of physiochemical properties of the viruses studied. Total mean log10 reductions range from 6.8 to >12.2 log10 as shown in Table 1. Table 1: Mean (cumulative) virus reduction factors   Mean Reduction Factor Mean Reduction Factor Cumulative Reduction   Pasteurization Two Ultrafiltration Factor [log10]   [log10] Steps [log10]   HIV-1 ≥ 6.7 ≥ 5.5 ≥ 12.2 BVDV ≥ 5.9 5.1 ≥ 11.0 PRV 4.3 ≥ 6.9 ≥ 11.2 HAV ≥ 5.4 ≥ 6.3 ≥ 11.7 CPV (0.9) 6.8 6.8 Last reviewed on RxList: 12/8/2004





Other reviews about Alpha-Proteinase Inhibitor on web:

Consumer information about the medication ALPHA-1-PROTEINASE INHIBITOR - INJECTION (Prolastin), includes side effects, drug interactions, recommended dosages, and storage ... ALPHA-1-PROTEINASE INHIBITOR - INJECTION (Prolastin) side effects ...


Learn about the prescription medication Zemaira (Alpha-Proteinase Inhibitor (Human)), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. Zemaira (Alpha-Proteinase Inhibitor (Human)) Drug Information ...


Alpha-proteinase inhibitor information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. Alpha-proteinase inhibitor - WrongDiagnosis.com


Alpha 1-Antitrypsin or α 1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin - Wikipedia, the free encyclopedia


Aventis Behring Alpha 1-Proteinase Inhibitor (Human), Intravenous Page 1 Alpha 1-Proteinase Inhibitor (Human) 1 Zemaira™ 2 3 R x only 4 5 DESCRIPTION 6 7 Alpha 1-Proteinase Inhibitor (Human ... Label - Alpha Proteinase Inhibitor (Human), Zemaira,


08938857 (Rev. June 2008) Alpha 1-Proteinase Inhibitor (Human) Pro las tin w FORINTRAVENOUSUSE ONLY DESCRIPTION Alpha 1-ProteinaseInhibitor (Human) , Prolastinwisa sterile, stable ... Alpha -Proteinase Inhibitor


1 14-7601-001 (Rev. Jan. 2002) Alpha 1-Proteinase Inhibitor (Human) Pro lastin w DESCRIPTION Alpha 1-Proteinase Inhibitor (Human), Prolastinwis a sterile, stable, lyophilized ... Alpha -Proteinase Inhibitor


Learn about Zemaira (Alpha-Proteinase Inhibitor (Human)) - Side Effects, Drug Interactions, Pictures, Patient Information on RxList Zemaira (Alpha-Proteinase Inhibitor (Human)) Patient Drug ...


Third Plasma-Derived Alpha-Proteinase Inhibitor OK'd for Use. Cheryl Thompson. BETHESDA, MD. 11 July 2003— The Food and Drug Administration (FDA) has approved the licensing of Zemaira ... News Article : Third Plasma-Derived Alpha-Proteinase Inhibitor OK ...


tnf alpha blocker and TNG alpha inhibitor information TNF alpha and TNG alpha inhibitor information





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